All pubs in England are set to shut except those local boozers on the Isles of Scilly.
The latest changes to the coronavirus tiering system will see every area of England currently in Tier 2 move up to either the third or fourth level of restrictions.
It means pubs must close their doors everywhere except for the Isles of Scilly, off the Cornish coast, which remains in Tier 1.
Boozers will have to shut by midnight tonight in a fresh blow to the hospitality industry that has been battered by the coronavirus pandemic this year.
The 11 pubs on the Isles of Scilly are the only ones that will remain open.
Tier 4 lockdown restrictions have been extended to 75% of England, with most of the rest of the country falling under Tier 3.
Pubs and restaurants in Tier 3 will still be allowed to offer a takeaway service.
Health Secretary Matt Hancock announced the changes to the tiers in the House of Commons this afternoon, outlining the threat of the contagious new variant sweeping across the country.
He warned that "cases are doubling fast" and putting huge pressure on the overcrowded NHS.
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Mr Hancock said: "Yesterday alone, 52,135 new cases are from the new variant, which is as much as 56% more contagious.
"Unfortunately the new variant is spreading across most of England.
"There are over 21,000 people in hospital with coronavirus right now.
"And we can see the impact this is having – the threat to life from this virus is real, and the pressures on the NHS is real too."
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The Covid-19 pandemic has had a huge impact on pubs. Businesses have opened and closed a number of times in an attempt to fit in with the changing protocols.
Industry experts say more than 5% of pubs have closed permanently directly due to the pandemic, with more set to follow in 2021.
It has had a "devastating" on the UK's pubs, according to the Campaign for Real Ale, and will hasten the decline of the industry.
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The news came as the Oxford/AstraZeneca vaccine was approved for use in the UK.
The UK has ordered 100 million doses, enough to vaccinate 50 million people, and Mr Hancock called it a "significant moment" in the fight against Covid-19.
It will be used alongside the Pfizer/BioNTech jab that is already being used.
He said: "The vaccine is the way out.
"It brings forward the date at which we're going to bring this pandemic to an end.
"This is a real British success story."
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